Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.

Abstract

In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.

• Authors: C Pierre-Audigier, C Surcouf, V Cadet-Daniel, A Namouchi, S Heng, A Murray, B Guillard, B Gicquel
• Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease (Int J Tuberc Lung Dis) Vol. 16 Issue 2 Pg. 221-3, i-ii (Feb 2012) ISSN: 1815-7920 [Electronic] France
• PMID: 22236923 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antitubercular Agents
• DNA, Bacterial
• Fluoroquinolones
• Pyrazinamide
• Amidohydrolases
• PncA protein, Mycobacterium tuberculosis

Topics

• Amidohydrolases (genetics)
• Antitubercular Agents (therapeutic use)
• Cambodia (epidemiology)
• DNA, Bacterial (genetics)
• Fluoroquinolones (therapeutic use)
• Genotype
• Humans
• Incidence
• Mutation
• Mycobacterium tuberculosis (drug effects, genetics, isolation & purification)
• Pyrazinamide (therapeutic use)
• Retrospective Studies
• Tuberculosis, Multidrug-Resistant (drug therapy, epidemiology, microbiology)