Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI.

Abstract

PURPOSE:

We evaluated the rate of successful characterization of gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT with CE-MRI, each in correlation with DOTATOC-PET.

METHODS AND MATERIALS:

8 patients with GEP-NET were imaged using CE-MRI (Gd-EOB-DTPA), CE-CT (Imeron 400) and DOTATOC-PET. Contrast-enhancement of normal liver-tissue and metastasis was quantified with ROI-technique. Tumor delineation was assessed with visual-score in blind-read-analysis by two experienced radiologists.

RESULTS:

Out of 40 liver metastases in patients with NETs, all were detected by CE-MRI and the lesion extent could be adequately assessed, whereas CT failed to detect 20% of all metastases. The blind-read-score of CT in arterial and portal phase was median -0.65 and -1.4, respectively, and 2.7 for delayed-MRI. The quantitative ROI-analysis presented an improved contrast-enhancement-ratio with a median of 1.2, 1.6 and 3.3 for CE-CT arterial, portal-phase and delayed-MRI respectively.

CONCLUSION:

Late CE-MRI was superior to CE-CT in providing additionally morphologic characterization and exact lesion extension of hepatic metastases from neuroendocrine tumor detected with DOTATOC-PET. Therefore, late enhanced Gd-EOB-DTPA-MRI seems to be the adequate imaging modality for combination with DOTATOC-PET to provide complementary (macroscopic and molecular) tumor characterization in hepatic metastasized NETs.

• Authors: F L Giesel, C Kratochwil, A Mehndiratta, S Wulfert, J H Moltz, C M Zechmann, H U Kauczor, U Haberkorn, S Ley
• Journal: European journal of radiology (Eur J Radiol) Vol. 81 Issue 10 Pg. 2820-5 (Oct 2012) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 22236704 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011. Published by Elsevier Ireland Ltd.

Chemical References

• Contrast Media
• Indium Radioisotopes
• Radiopharmaceuticals
• gadolinium ethoxybenzyl DTPA
• iomeprol
• Iopamidol
• Gadolinium DTPA
• Octreotide
• Edotreotide

Topics

• Contrast Media (administration & dosage)
• Female
• Gadolinium DTPA (administration & dosage)
• Humans
• Indium Radioisotopes
• Iopamidol (administration & dosage, analogs & derivatives)
• Magnetic Resonance Imaging (methods)
• Male
• Neuroendocrine Tumors (diagnosis)
• Octreotide (analogs & derivatives)
• Positron-Emission Tomography (methods)
• Radiopharmaceuticals
• Reproducibility of Results
• Sensitivity and Specificity
• Statistics as Topic
• Tomography, X-Ray Computed (methods)