B-type natriuretic peptide in children with atrial or ventricular septal defect: a cardiac catheterization study.

Abstract

In this study, we investigated the relationship between plasma B-type natriuretic peptide (BNP) levels and hemodynamics from cardiac catheterization in pediatric patients with atrial or ventricular septal defect. A total of 59 patients were studied including 80% of patients had Qp/Qs > 1.5 and 25% of patients had pulmonary hypertension. The mean BNP value and BNP z-score were 10.9 ± 11.2 pg/mL and -0.28 ± 1.7 (-2.85 to 3.29), respectively. There was a statistically significant linear correlation between BNP value and the size of defects (r = 0.303, p = 0.002) and a trend toward to positive correlation between BNP value and Qp/Qs ratio (r = 0.183, p = 0.166) among all patients. To identify patients with a Qp/Qs ratio >1.5, the sensitivity and specificity were 28%, 100% in all patients at a plasma BNP cut-off point of 15 pg/mL. We concluded that a BNP > 15 pg/mL would help identify patients who need further intervention.

• Authors: Sheng-Ling Jan, Yun-Ching Fu, Betau Hwang, Shing-Jong Lin
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 17 Issue 2 Pg. 166-71 (Mar 2012) ISSN: 1366-5804 [Electronic] England
• PMID: 22235950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Natriuretic Peptide, Brain

Topics

• Adolescent
• Biomarkers (blood)
• Cardiac Catheterization
• Child
• Child, Preschool
• Female
• Heart Atria (metabolism, physiopathology)
• Heart Septal Defects, Atrial (blood, complications, physiopathology)
• Heart Septal Defects, Ventricular (blood, complications, physiopathology)
• Hemodynamics
• Humans
• Hypertension, Pulmonary (blood, complications, physiopathology)
• Infant
• Male
• Natriuretic Peptide, Brain (blood)
• Sensitivity and Specificity