Mechanisms of hemostimulating effects of granulocytic CSF and pantohematogen under conditions of cytostatic myelosuppression.

Abstract

We compared hemostimulating activity of pantohematogen and granulocytic CSF under conditions of 5-fluorouracil-induced cytostatic myelosuppression. It was found that activation of hemopoiesis regeneration under the effect of the test preparations was accompanied by the development of hyperplasia of the granulocytic and monocytic hemopoietic bone marrow lineages and more rapid recovery of the count of pholymorphonuclear leukocytes and monocytes in the peripheral blood (more marked under the effect of pantohematogen) followed by neutrophilia and monocytosis.

• Authors: L A Miroshnichenko, V V Shdanov, G N Zyuz'kov, E V Simanina, L A Stavrova, E V Udut, T Yu Khrichkova, M Yu Minakova, V E Goldberg, A M Dygai
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 150 Issue 6 Pg. 702-6 (Apr 2011) ISSN: 1573-8221 [Electronic] United States
• PMID: 22235422 (Publication Type: Journal Article)

Chemical References

• Biological Factors
• pantohematogen
• Granulocyte-Macrophage Colony-Stimulating Factor
• Cyclophosphamide
• Fluorouracil

Topics

• Animals
• Biological Factors (pharmacology)
• Bone Marrow (drug effects)
• Bone Marrow Cells (drug effects)
• Cyclophosphamide (pharmacology)
• Female
• Fluorouracil (pharmacology)
• Granulocyte-Macrophage Colony-Stimulating Factor (pharmacology)
• Hematopoiesis (drug effects)
• Hyperplasia
• Leukocyte Count
• Mice
• Mice, Inbred CBA
• Neutrophils