Abstract | BACKGROUND: METHODS AND MATERIALS: From June 2007 to July 2009 in a randomized controlled trial, 204 patients with nonperforated appendicitis underwent an open appendectomy; 122 male and 82 female with mean age of 25 years. Among these, 102 (case group) received oral metronidazole and in 102 (control group) metronidazole was administered intravenously before surgery. The rate of wound infection and duration of the postoperative hospital stay was studied in the two groups. RESULTS: The rate of wound infection was not significantly different in the two groups. (6% and 4% in study and control group, respectively, P = 0.861). Also the hospital stay was equal in two groups (2.3 days and 2.7 days in study and control group, respectively, P = 0.293). CONCLUSION: Single dose of oral metronidazole prior to operation can provide a sufficient prophylaxis for nonperforated appendicitis; so, it can be substitute the parental route of antibiotic administration.
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Authors | Hassan Ravari, Ali Jangjoo, Jalal Motamedifar, Kasra Moazzami |
Journal | Clinical and experimental gastroenterology
(Clin Exp Gastroenterol)
Vol. 4
Pg. 273-6
( 2011)
ISSN: 1178-7023 [Electronic] New Zealand |
PMID | 22235170
(Publication Type: Journal Article)
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