Abstract | BACKGROUND/AIMS: Studies investigating the association between p53 codon 72 polymorphism and colorectal cancer risk report conflicting results. In order to clarify this, we carried out a meta-analysis using published data to obtain more precise estimates of risk. METHODOLOGY: Electronic searches of PubMed and EMBASE were conducted to select studies for this meta- analysis. The principal outcome measure was the odds ratio (OR) with 95% confidence interval (CI) for the risk of colorectal cancer associated with p53 codon 72 genotype. RESULTS: We identified seven epidemiological studies, which included 1964 colorectal cancer cases and 2943 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [ Arg/Arg (OR=0.86, 95% CI=0.68, 1.08); Pro/Pro (OR=1.27, 95% CI=0.96, 1.68); Pro/Arg (OR=1.04, 95% CI=0.92, 1.17)] between colorectal cancer and non- cancer patients. When stratifying for race, we found that patients with colorectal cancer had a significantly higher frequency of Pro/ Pro (OR=1.79, 95% CI=1.37, 2.35) and lower frequency of Arg/Arg (OR=0.66, 95% CI=0.44, 0.98) than controls among Asians. No statistical association was found between this genotype and alcohol, tobacco, stage, histological differentiation, lymph node metastasis of colorectal cancer. CONCLUSIONS: Our meta-analysis suggests that the p53 codon 72 polymorphism may be associated with colorectal cancer among Asians.
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Authors | Yao Liu, Huadong Qin, Yi Zhang, Tiefeng Shi, Bing Liu, Yu Sun, Yanfei Ma |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2011 Nov-Dec
Vol. 58
Issue 112
Pg. 1926-9
ISSN: 0172-6390 [Print] Greece |
PMID | 22234063
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Codon
- Colorectal Neoplasms
(genetics, pathology)
- Genes, p53
- Genotype
- Humans
- Lymphatic Metastasis
- Polymorphism, Genetic
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