Abstract | PURPOSE: METHODS: Samples of aqueous humor were obtained from 7 patients with Coats' disease and 15 age-matched patients with congenital cataracts as controls. Nitrite and nitrate (NOx), the stable end products of NO, were detected by the Griess reaction, and VEGF levels were assessed by enzyme-linked immunosorbent assay. RESULTS: The aqueous humor NOx and VEGF levels were elevated in the eyes of patients with Coats' disease compared with those of controls (P=0.001 and P<0.001, respectively). The median NOx level was 55.2 μM (range, 23.0-75.3 μM) in the Coats' disease group and 18.8 μM (range, 8.7-36.2 μM) in the control group. The median VEGF level was 731.7 pg/mL (range, 288.3-1364.3 pg/mL) in the Coats' disease group and 33.3 pg/mL (range, 9.0-96.8 pg/mL) in the control group. No correlation was observed between the aqueous humor concentrations of NOx and VEGF. CONCLUSIONS:
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Authors | Han Zhang, Zhe-Li Liu |
Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
Vol. 28
Issue 4
Pg. 397-401
(Aug 2012)
ISSN: 1557-7732 [Electronic] United States |
PMID | 22233441
(Publication Type: Journal Article)
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Chemical References |
- Vascular Endothelial Growth Factor A
- Nitric Oxide
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Topics |
- Adolescent
- Aqueous Humor
(metabolism)
- Asian People
- Cataract
(congenital, metabolism)
- Child
- Child, Preschool
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Functional Laterality
- Humans
- Male
- Nitric Oxide
(metabolism)
- Retinal Telangiectasis
(metabolism)
- Vascular Endothelial Growth Factor A
(metabolism)
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