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Pazopanib for the treatment of breast cancer.

AbstractINTRODUCTION:
Several clinical trials have shown clinical benefit of angiogenesis inhibitors in the treatment of solid tumors. Pazopanib is a multitargeted tyrosine kinase inhibitor that is currently approved for the treatment of patients with advanced renal cell carcinoma (RCC).
AREAS COVERED:
In this article, the clinical development of pazopanib as it relates to breast cancer is reviewed including its evaluation in clinical trials and side effect profile. Preclinical data show the anti-tumor activity of pazopanib in animal models. Several trials of pazopanib monotherapy and combination therapy in breast cancer have been completed or are underway.
EXPERT OPINION:
The development of biomarkers predictive of response and toxicity to angiogenesis inhibitors remains a challenging endeavor and is necessary to help guide treatment decision.
AuthorsLaleh Amiri-Kordestani, Antoinette R Tan, Sandra M Swain
JournalExpert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 21 Issue 2 Pg. 217-25 (Feb 2012) ISSN: 1744-7658 [Electronic] England
PMID22233389 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Angiogenesis Inhibitors
  • Biomarkers, Tumor
  • Indazoles
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • pazopanib
  • Protein-Tyrosine Kinases
Topics
  • Angiogenesis Inhibitors (therapeutic use)
  • Biomarkers, Tumor
  • Breast Neoplasms (drug therapy, genetics)
  • Female
  • Humans
  • Indazoles
  • Protein Kinase Inhibitors (therapeutic use)
  • Protein-Tyrosine Kinases (antagonists & inhibitors)
  • Pyrimidines (therapeutic use)
  • Sulfonamides (therapeutic use)

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