Abstract | OBJECTIVE: Increased glucocorticoid metabolite excretion and enhanced expression and activity of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue are closely correlated with obesity and its detrimental consequences. Weight loss ameliorates the latter. The aim of this study was to explore whether increased glucocorticoid exposure in obesity is improved with substantial weight loss and thus is a consequence rather than a cause of obesity. DESIGN AND PATIENTS: A prospective cohort study in 31 women. MEASUREMENTS: RESULTS: CONCLUSION:
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Authors | E Rask, K Simonyte, L Lönn, M Axelson |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 78
Issue 5
Pg. 700-5
(May 2013)
ISSN: 1365-2265 [Electronic] England |
PMID | 22233384
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Tetrahydrocortisone
- Tetrahydrocortisol
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- Cortisone
- Hydrocortisone
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Topics |
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
(metabolism)
- Adult
- Cohort Studies
- Cortisone
(urine)
- Female
- Humans
- Hydrocortisone
(urine)
- Middle Aged
- Obesity
(metabolism, urine)
- Prospective Studies
- Tetrahydrocortisol
(metabolism)
- Tetrahydrocortisone
(metabolism)
- Weight Loss
(physiology)
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