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[Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions].

Abstract
Experiments on rats showed that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate increases cerebral blood flow in the system of carotid arteries both in intact animals and under conditions of global transient ischemia. In combination with tropoxin, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate enhances the blood flow in the inner carotid artery of intact rats and the local blood flow under conditions of global transient ischemia. A combination of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and tropoxin increases baseline cerebral blood flow and decreases the constrictor reaction of cerebral blood vessels to 5HT(2B/2C) receptor agonist meta-chlorophenylpiperazine.
AuthorsT S Gan'shina, A A Gorbunov, A V Gnezdilova, I N Kurdiumov, N I Avdiunina, B M Piatin, R S Mirzoian
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 74 Issue 8 Pg. 17-22 ( 2011) ISSN: 0869-2092 [Print] Russia (Federation)
PMID22232909 (Publication Type: Journal Article)
Chemical References
  • 3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane
  • Antioxidants
  • Aza Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Drug Combinations
  • Neuroprotective Agents
  • Picolines
  • Piperazines
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • emoxypine succinate
  • 1-(3-chlorophenyl)piperazine
Topics
  • Animals
  • Antioxidants (administration & dosage, therapeutic use)
  • Aza Compounds (administration & dosage, therapeutic use)
  • Brain (blood supply, drug effects, physiopathology)
  • Brain Ischemia (drug therapy, pathology, physiopathology)
  • Bridged Bicyclo Compounds, Heterocyclic (administration & dosage, therapeutic use)
  • Carotid Artery, Internal (drug effects, physiopathology)
  • Cerebrovascular Circulation (drug effects)
  • Disease Models, Animal
  • Drug Combinations
  • Male
  • Neuroprotective Agents (administration & dosage, therapeutic use)
  • Picolines (administration & dosage, therapeutic use)
  • Piperazines (administration & dosage, adverse effects)
  • Rats
  • Serotonin Antagonists (administration & dosage, therapeutic use)
  • Serotonin Receptor Agonists (administration & dosage, adverse effects)

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