Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infections.

Abstract

BC-3781 is a novel semisynthetic pleuromutilin antimicrobial agent developed as an intravenous and oral therapy for acute bacterial skin and skin structure infections (ABSSSI) and respiratory tract infections (RTI). BC-3781 and comparator agents were tested by the broth microdilution method against 1,893 clinical Gram-positive organisms predominantly causing ABSSSI. BC-3781 exhibited potent activity against methicillin-resistant Staphylococcus aureus (MIC(50/90), 0.12/0.25 μg/ml), coagulase-negative staphylococci (MIC(50/90), 0.06/0.12 μg/ml), β-hemolytic streptococci (MIC(50/90), 0.03/0.06 μg/ml), viridans group streptococci (MIC(50/90), 0.12/0.5 μg/ml), and Enterococcus faecium (including vancomycin-nonsusceptible strains) (MIC(50/90), 0.12/2 μg/ml). Compared with other antibiotics in use for the treatment of ABSSSI, BC-3781 displayed the lowest MICs and only a minimal potential for cross-resistance with other antimicrobial classes.

• Authors: Helio S Sader, Douglas J Biedenbach, Susanne Paukner, Zrinka Ivezic-Schoenfeld, Ronald N Jones
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 56 Issue 3 Pg. 1619-23 (Mar 2012) ISSN: 1098-6596 [Electronic] United States
• PMID: 22232289 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Diterpenes
• Drugs, Investigational
• Vancomycin

Topics

• Anti-Bacterial Agents (pharmacology)
• Diterpenes (pharmacology)
• Drugs, Investigational
• Enterococcus (drug effects, growth & development, isolation & purification)
• Humans
• Methicillin-Resistant Staphylococcus aureus (drug effects, growth & development, isolation & purification)
• Microbial Sensitivity Tests
• Skin (microbiology)
• Skin Diseases, Bacterial (microbiology)
• Staphylococcus (drug effects, growth & development, isolation & purification)
• Streptococcus (drug effects, growth & development, isolation & purification)
• Vancomycin (pharmacology)