Hydrogel nanoparticles with covalently linked coomassie blue for brain tumor delineation visible to the surgeon.

Abstract

Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor-targeting deep-blue nanoparticle-based visible contrast agent is described, which, for the first time, offers in vivo tumor-specific visible color staining. This technology thus enables color-guided tumor resection in real time, with no need for extra equipment or special lighting conditions. The visual contrast agent consists of polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue color contrast), which are surface-conjugated with polyethylene glycol and F3 peptides for efficient in vivo circulation and tumor targeting, respectively.

• Authors: Guochao Nie, Hoe Jin Hah, Gwangseong Kim, Yong-Eun Koo Lee, Ming Qin, Tanvi S Ratani, Panagiotis Fotiadis, Amber Miller, Akiko Kochi, Di Gao, Thomas Chen, Daniel A Orringer, Oren Sagher, Martin A Philbert, Raoul Kopelman
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 8 Issue 6 Pg. 884-91 (Mar 26 2012) ISSN: 1613-6829 [Electronic] Germany
• PMID: 22232034 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Hydrogels
• Rosaniline Dyes
• Coomassie blue

Topics

• Brain Neoplasms (pathology)
• General Surgery
• Humans
• Hydrogels
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Nanoparticles
• Rosaniline Dyes (chemistry)
• Tumor Cells, Cultured
• Workforce