Abstract |
This study evaluated neurocognitive functioning in 26 youth with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and primarily obsessive-compulsive disorder (OCD) symptoms. Marked impairment in visuospatial recall memory (as assessed using the Rey-Osterrieth Complex Figure Test) was observed in spite of average to above-average performance on academic and other neurocognitive measures. Group A beta-hemolytic Streptococcus titer elevations were associated with worse performance on tasks of neurocognitive and executive ability (Stroop Color-Word Interference Test), visuospatial memory, and fine motor speed (finger tapping) as well as elevated obsessive-compulsive symptom severity.
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Authors | Adam B Lewin, Eric A Storch, P Jane Mutch, Tanya K Murphy |
Journal | The Journal of neuropsychiatry and clinical neurosciences
(J Neuropsychiatry Clin Neurosci)
Vol. 23
Issue 4
Pg. 391-8
( 2011)
ISSN: 1545-7222 [Electronic] United States |
PMID | 22231309
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adolescent
- Antistreptolysin
(blood)
- Autoimmune Diseases
(complications)
- Child
- Child, Preschool
- Cognition Disorders
(diagnosis, etiology, microbiology)
- Female
- Humans
- Longitudinal Studies
- Male
- Neuropsychological Tests
- Obsessive-Compulsive Disorder
(complications)
- Psychiatric Status Rating Scales
- Streptococcal Infections
(complications)
- Streptococcus
(pathogenicity)
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