Complete remission with tyrosine kinase inhibitors in renal cell carcinoma.

Abstract

PURPOSE:

Complete remission (CR) is uncommon during treatment for metastatic renal cell carcinoma (mRCC) with tyrosine kinase inhibitors (TKIs), but it may occur in some patients. It remains a matter of debate whether therapy should be continued after CR.

METHODS:

A multicenter, retrospective analysis of a series of patients with mRCC who obtained CR during treatment with TKIs (sunitinib or sorafenib), either alone or with local treatment (surgery, radiotherapy, or radiofrequency ablation), was performed.

RESULTS:

CR was identified in 64 patients; 36 patients had received TKI treatment alone and 28 had also received local treatment. Most patients had clear cell histology (60 of 64 patients), and all had undergone previous nephrectomy. The majority of patients were favorable or intermediate risk; however, three patients were poor risk. Most patients developed CR during sunitinib treatment (59 of 64 patients). Among the 36 patients who achieved CR with TKI alone, eight continued TKI treatment after CR, whereas 28 stopped treatment. Seventeen patients who stopped treatment (61%) are still in CR, with a median follow-up of 255 days. Among the 28 patients in CR after TKI plus local treatment, 25 patients stopped treatment, and 12 of these patients (48%) are still in CR, with a median follow-up of 322 days.

CONCLUSION:

CR can occur after TKI treatment alone or when combined with local treatment. CR was observed at every metastatic site and in every prognostic group.

• Authors: Laurence Albiges, Stéphane Oudard, Sylvie Negrier, Armelle Caty, Gwenaëlle Gravis, Florence Joly, Brigitte Duclos, Lionel Geoffrois, Frédéric Rolland, Aline Guillot, Brigitte Laguerre, Eric Legouffe, Frédéric Kohser, Pierre-Yves Dietrich, Christine A Theodore, Bernard Escudier
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 30 Issue 5 Pg. 482-7 (Feb 10 2012) ISSN: 1527-7755 [Electronic] United States
• PMID: 22231040 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antineoplastic Agents
• Benzenesulfonates
• Indoles
• Phenylurea Compounds
• Protein Kinase Inhibitors
• Pyridines
• Pyrroles
• Niacinamide
• Sorafenib
• Protein-Tyrosine Kinases
• Sunitinib

Topics

• Adult
• Aged
• Antineoplastic Agents (therapeutic use)
• Benzenesulfonates (therapeutic use)
• Carcinoma, Renal Cell (drug therapy, secondary, surgery)
• Feasibility Studies
• Female
• Humans
• Indoles (therapeutic use)
• Kidney Neoplasms (drug therapy, pathology, surgery)
• Male
• Medical Records
• Middle Aged
• Molecular Targeted Therapy
• Nephrectomy
• Niacinamide (analogs & derivatives)
• Phenylurea Compounds
• Protein Kinase Inhibitors (therapeutic use)
• Protein-Tyrosine Kinases (antagonists & inhibitors)
• Pyridines (therapeutic use)
• Pyrroles (therapeutic use)
• Remission Induction
• Retrospective Studies
• Sorafenib
• Sunitinib
• Surveys and Questionnaires
• Treatment Outcome