Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study.

Abstract

We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide polymorphisms. The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m(2), and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m(2)). The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele. The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P <0.01). Thus, the rs10509291, rs7894483, and rs10823116 alleles were associated with a high BMI (> 23 Kg/m(2)) and with overweight in this non-diabetic Chinese population.

• Authors: Juan Zheng, Lu-Lu Chen, Fangxi Xiao, Xiang Hu, Xiulin Deng, Huiqing Li
• Journal: Endocrine journal (Endocr J) Vol. 59 Issue 3 Pg. 229-37 ( 2012) ISSN: 1348-4540 [Electronic] Japan
• PMID: 22230810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• SIRT1 protein, human
• Sirtuin 1

Topics

• Adult
• Aged
• Alleles
• Asian People (genetics)
• Body Mass Index
• Case-Control Studies
• China
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Male
• Middle Aged
• Overweight (genetics)
• Polymorphism, Single Nucleotide
• Sirtuin 1 (genetics)