Usefulness of F-18 FDG PET/CT in the follow-up of POEMS syndrome after autologous peripheral blood stem cell transplantation.

Abstract

We report a case of a patient with relapse of POEMS syndrome (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) that occurred 6 years after an autologous peripheral blood stem cell transplantation. F-18 FDG PET/CT showed several hypermetabolic as well as nonhypermetabolic bone lesions. Based on these findings, the patient was referred for radiotherapy to the hypermetabolic bone lesions. After autologous peripheral blood stem cell transplantation, F-18 FDG PET/CT may play a pivotal role in detecting new bone lesions in patients with POEMS syndrome, which may be treated by a focalized radiotherapy and/or systemic therapy.

• Authors: Antonella Stefanelli, Giorgio Treglia, Lucia Leccisotti, Luca Laurenti, Marco Luigetti, Mario Sabatelli, Alessandro Giordano
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 37 Issue 2 Pg. 181-3 (Feb 2012) ISSN: 1536-0229 [Electronic] United States
• PMID: 22228347 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Fluorodeoxyglucose F18
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Multimodal Imaging
• POEMS Syndrome (diagnostic imaging, etiology)
• Peripheral Blood Stem Cell Transplantation (adverse effects)
• Positron-Emission Tomography
• Tomography, X-Ray Computed
• Transplantation, Autologous
• Whole Body Imaging