Antifungal activity of plumericin and isoplumericin.

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

• Authors: Dharmendra Singh, Umakant Sharma, Parveen Kumar, Yogesh K Gupta, M P Dobhal, Sarman Singh
• Journal: Natural product communications (Nat Prod Commun) Vol. 6 Issue 11 Pg. 1567-8 (Nov 2011) ISSN: 1934-578X [Print] United States
• PMID: 22224260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Indenes
• Iridoids
• Plant Extracts
• isoplumericin
• plumericin

Topics

• Antifungal Agents (isolation & purification)
• Apocynaceae (chemistry)
• Candida (drug effects)
• Cryptococcus neoformans (drug effects)
• Indenes (isolation & purification)
• Iridoids (isolation & purification)
• Microbial Sensitivity Tests
• Plant Extracts (chemistry)