[Experimental hemorrhagic stroke: the effect of the peptide preparation cortexin in the formation of Hb-NO-complexes and other blood paramagnetic centers].

Abstract

Using electronic paramagnetic resonance (EPR), we studied the effect of the peptide cortexin on the content of hemoglobin nitrozyl complexes (Hb-NO-complexes) and other paramagnetic centers (transferrin, methemoglobin) in the blood of rats of Krushynsky-Molodkina line in the experimental hemorrhagic stroke induced by acoustic stress. After the acoustic exposure, the level of Hb-NO-complexes have increased by more than 6 times. The intensity of the EPR signal of the plasma peptide transferrin increased by 1,5 times. The level of blood methemoglobin was also elevated, though not significantly, after the acoustic stress. Cortexin substantially reduces the formation of Hb-NO-complexes and, therefore, the level of nitride oxide while the contents of transferrin and methemoglobin remain intact.

• Authors: V P Reutov, L M Baĭder, Z V Kuropteva, A L Krushinskiĭ, V S Kuzenkov, Zh T Moldaliev, O K Granstrem
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 111 Issue 8 Pt 2 Pg. 56-61 ( 2011) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 22224248 (Publication Type: Journal Article)

Chemical References

• Hemoglobins
• Intercellular Signaling Peptides and Proteins
• Peptides
• Transferrin
• nitrosyl hemoglobin
• cortexin
• Methemoglobin

Topics

• Animals
• Disease Models, Animal
• Electron Spin Resonance Spectroscopy
• Hemoglobins (analysis)
• Intercellular Signaling Peptides and Proteins
• Intracranial Hemorrhages (blood, drug therapy)
• Male
• Methemoglobin (analysis)
• Peptides (therapeutic use)
• Rats
• Rats, Inbred Strains
• Transferrin (analysis)