Resveratrol in human cancer chemoprevention--choosing the 'right' dose.

Abstract

There is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has provided insights into its pharmacokinetics, and data on its human antineoplastic pharmacodynamics start to emerge. It is likely that resveratrol will be developed further in the clinic as a putative cancer chemopreventive agent. The question that remains unresolved is: What is the most suitable dose of resveratrol for effective cancer preventive intervention? Mechanistic studies in cells in vitro have almost invariably used concentrations of resveratrol in the 10(-5) to 10(-4)  M range, which is much higher than those which can be achieved in the human biophase after consumption of doses up to 1 g. Many of the preclinical efficacy studies in rodent models of carcinogenesis have employed doses which are dramatically above those which can be ingested with the diet. New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses.

• Authors: Edwina Scott, William P Steward, Andreas J Gescher, Karen Brown
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 56 Issue 1 Pg. 7-13 (Jan 2012) ISSN: 1613-4133 [Electronic] Germany
• PMID: 22218912 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents, Phytogenic
• Stilbenes
• Resveratrol

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Humans
• Neoplasms (prevention & control)
• Resveratrol
• Stilbenes (administration & dosage, therapeutic use)