Activity of compound G2 isolated from alfalfa roots in experimental dermatophyte infection.

Abstract

Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of the untreated lesions which healed spontaneously (P less than 0.01).

• Authors: R Evron, M Guizie, U Zehavi, I Polacheck
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 34 Issue 8 Pg. 1600-1 (Aug 1990) ISSN: 0066-4804 [Print] United States
• PMID: 2221870 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Triterpenes
• medicagenic acid-3-O-glucopyranoside

Topics

• Animals
• Antifungal Agents (therapeutic use)
• Female
• Guinea Pigs
• Macaca mulatta
• Medicago sativa (analysis)
• Tinea (drug therapy, microbiology)
• Triterpenes (therapeutic use)