Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy.

Abstract

Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.

• Authors: Agustín Díaz, Vipin Saxena, Julissa González, Amanda David, Barbara Casañas, Carrie Carpenter, James D Batteas, Jorge L Colón, Abraham Clearfield, M Delwar Hussain
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 48 Issue 12 Pg. 1754-6 (Feb 07 2012) ISSN: 1364-548X [Electronic] England
• PMID: 22218458 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: This journal is © The Royal Society of Chemistry 2012

Chemical References

• Antibiotics, Antineoplastic
• Drug Carriers
• zirconium phosphate
• Doxorubicin
• Zirconium

Topics

• Antibiotics, Antineoplastic (administration & dosage, pharmacology)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Doxorubicin (administration & dosage, pharmacology)
• Drug Carriers (chemistry)
• Female
• Humans
• Nanostructures (chemistry, ultrastructure)
• Zirconium (chemistry)