Abstract | OBJECT: METHODS: KK mice were divided into the following groups: KK control group, with saline treatment; KK Tβ(4) group, with daily Tβ(4) 100ng/10g body weight intraperitoneal injection for 12 weeks. Non-diabetic C57BL mice were used as normal control. OGTT, plasma insulin, HbA1c, serum adiponectin, Tβ(4), cholesterol, and triglyceride were measured before and after Tβ(4) treatment. The phosphorylated AKT and total AKT protein levels of skeletal muscle from all groups were determined. RESULTS: After Tβ(4) treatment, repeat OGTT showed a significant decrease in glucose profiles in the KK Tβ(4) group compared with the KK control group. The KK-Tβ(4) group had reduced mean HbA1c and triglyceride levels, and increased adiponectin compared with KK control group. C57BL mice showed normal glucose homeostasis. The phosphorylated AKT levels of skeletal muscle were significantly increased in KK Tβ(4) group compared with KK control group after glucose stimulation. C57BL mice showed no changes in phosphorylated AKT levels after Tβ(4) treatment. CONCLUSIONS:
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Authors | Jian Zhu, Li-Ping Su, Lei Ye, Kok-Onn Lee, Jian-Hua Ma |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 96
Issue 1
Pg. 53-9
(Apr 2012)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 22217673
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- thymosin beta(4)
- Thymosin
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Topics |
- Animals
- Blotting, Western
- Glucose Tolerance Test
- Hyperglycemia
(drug therapy)
- Insulin Resistance
(physiology)
- Mice
- Thymosin
(therapeutic use)
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