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Recurrent congenital fibrosarcoma with heart metastases.

Abstract
Congenital fibrosarcomas are malignant tumors that arise in soft tissues. In infants this unique tumor does not commonly metastasize, even though there may be local recurrences. We report here a boy who had congenital fibrosarcoma in his right foot, which was completely excised at the age of 3 days. Four months later, a solitary encapsulated metastasis emerged in thoracic chest wall, which was operated. During adjuvant chemotherapy he developed histologically confirmed fibrosarcoma metastases in the heart. After extended treatment with cyclophosphamide/topotecan and gemcitabine/docetaxel, the heart tumors disappeared and he has been in complete remission for 3 years.
AuthorsOlli Lohi, Martine Vornanen, Marketta Kähkönen, Kim Vettenranta, Katriina Parto, Mikko Arola
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 34 Issue 5 Pg. e202-5 (Jul 2012) ISSN: 1536-3678 [Electronic] United States
PMID22217490 (Publication Type: Case Reports, Journal Article)
Chemical References
  • ETV6-NTRK3 fusion protein, human
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • Quinazolines
  • Erlotinib Hydrochloride
Topics
  • Erlotinib Hydrochloride
  • Female
  • Fibrosarcoma (congenital, pathology, therapy)
  • Heart Neoplasms (secondary)
  • Humans
  • Infant
  • Oncogene Proteins, Fusion (genetics)
  • Pregnancy
  • Protein Kinase Inhibitors (therapeutic use)
  • Quinazolines (therapeutic use)
  • Recurrence

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