Abstract | BACKGROUND: The diagnosis of uterine smooth muscle tumors depends on a combination of microscopic features. However, a small number of these tumors still pose difficult diagnostic challenges. AIM: MATERIALS AND METHODS: Immunohistochemical expression of PR and p53 was investigated in 41 uterine smooth muscle tumors comprising: 15 LMS, 4 STUMP, 6 ALM and 16 LM. Quantitative evaluation of PR and p53 expression was graded on a scale from 0 to 3+. RESULTS:
Leiomyosarcomas showed reduced PR expression. All LMs as well as ALMs and STUMP were stained intensely for PR. Conversely, LMS was strongly stained with p53, while the three non-sarcomatous groups (STUMP, ALM, LM) were either entirely negative or weakly stained for p53. Regarding both PR and p53 expression, the difference between the LMS group and the three non-sarcomatous groups was highly significant (p < 0.001). Combined high PR - low p53 expression was seen in all the 26 examined cases of the non-sarcomatous group including the STUMP cases and none of the LMS cases. Therefore, it represents a "benign" profile with 100% specificity in diagnosis of a non-sarcomatous tumor. CONCLUSION: Immunohistochemistry for PR and p53 is valuable as an adjunct tool to morphological assessment of problematic uterine smooth muscle tumors.
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Authors | Iman H Hewedi, Nehal A Radwan, Lobna S Shash |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 7
Pg. 1
(Jan 05 2012)
ISSN: 1746-1596 [Electronic] England |
PMID | 22217299
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Progesterone
- TP53 protein, human
- Tumor Suppressor Protein p53
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Topics |
- Biomarkers, Tumor
(analysis)
- Chi-Square Distribution
- Diagnosis, Differential
- Egypt
- Female
- Humans
- Immunohistochemistry
- Leiomyoma
(chemistry, pathology)
- Leiomyosarcoma
(chemistry, pathology)
- Predictive Value of Tests
- Prognosis
- Receptors, Progesterone
(analysis)
- Retrospective Studies
- Tumor Suppressor Protein p53
(analysis)
- Uterine Neoplasms
(chemistry, pathology)
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