Abstract | AIMS: MAIN METHODS: The effect of aclidinium on urine and electrolyte excretion, renal function and voiding cystometry was analysed in conscious water-loaded Wistar rats (10-1000 μg/kg, s.c.), anaesthetised Beagle dogs (1000 μg/kg, i.v.) and anaesthetised guinea pigs (3-100μg/kg, intratracheally), respectively. Aclidinium plasma levels were determined in an independent study. Active comparators were tiotropium (all studies) and ipratropium (cystometry only). KEY FINDINGS: Aclidinium 1000 μg/kg had no effect on urine excretion in rats, in contrast to tiotropium 100 μg/kg which significantly decreased this parameter (p<0.05). Aclidinium 1000 μg/kg also had no effect on renal function in Beagle dogs. In guinea pigs, aclidinium 3-100 μg/kg had no effect on urinary bladder function, whereas tiotropium and ipratropium 100 μg/kg decreased the peak micturition pressure (p<0.05), increased the volume of urine retained in the bladder (p<0.01) and showed a trend to decrease the volume of urine excreted. SIGNIFICANCE: Aclidinium had no significant effect on urinary and renal function in the animal models studied. These results, together with the rapid plasma clearance of aclidinium reported previously, suggest a lower propensity to induce urinary retention in humans than tiotropium and ipratropium.
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Authors | Amadeu Gavaldà, Jordi Gras, Josep Llupià, Jordi Aubets, Jorge Beleta, Jesús Llenas |
Journal | Life sciences
(Life Sci)
Vol. 90
Issue 7-8
Pg. 301-5
(Feb 13 2012)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 22213116
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Muscarinic Antagonists
- Scopolamine Derivatives
- Tropanes
- aclidinium bromide
- Tiotropium Bromide
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Topics |
- Animals
- Dogs
- Female
- Guinea Pigs
- Kidney
(drug effects)
- Kidney Function Tests
- Male
- Muscarinic Antagonists
(pharmacology, therapeutic use)
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Rats
- Rats, Wistar
- Scopolamine Derivatives
(pharmacology, therapeutic use)
- Time Factors
- Tiotropium Bromide
- Tropanes
(pharmacology, therapeutic use)
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