HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated.

Abstract
The role of adenosine in hypoxia-induced vasodilation was examined in the intestine of pentobarbital sodium-anesthetized cats. A hollow-fiber fetal oxygenator was used to selectively reduce the PO2 of the blood supplying the superior mesenteric artery, thereby inducing hypoxia in the intestines. Decreasing the PO2 from 109 to 38 Torr caused vascular resistance to decrease from 10.2 to 7.5 Torr.kg.min.ml-1, a decrease of 2.7 Torr.kg.min.ml-1 or 24%. During selective adenosine receptor blockade with 8-phenyltheophylline, the same decrease in PO2 (from 109 to 40 Torr) produced a similar decrease in resistance from 5.7 to 3.4 Torr.kg.min.ml-1 or a difference of 2.3 Torr.kg.min.ml-1 (-36%). Thus adenosine is not the mediator of hypoxia-induced vasodilation in the feline intestine because blockade of the vasodilating effects of exogenous and presumably endogenous adenosine did not affect the observed decrease in resistance.
AuthorsL K Lockhart, W W Lautt
JournalThe American journal of physiology (Am J Physiol) Vol. 259 Issue 4 Pt 1 Pg. G605-10 (Oct 1990) ISSN: 0002-9513 [Print] United States
PMID2221070 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Purinergic
  • Theophylline
  • 8-phenyltheophylline
  • Adenosine
  • Isoproterenol
  • Oxygen
Topics
  • Adenosine (pharmacology, physiology)
  • Animals
  • Cats
  • Hypoxia (physiopathology)
  • Isoproterenol (pharmacology)
  • Mesenteric Arteries (physiology, physiopathology)
  • Oxygen (blood)
  • Partial Pressure
  • Receptors, Purinergic (drug effects, physiology)
  • Theophylline (analogs & derivatives, pharmacology)
  • Vasodilation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: