Acute kidney injury due to sodium bromate intoxication: a report of two cases.

Abstract

Sodium bromate is a strong oxidant used as a neutralizing solution in hair permanents, as well as an auxiliary agent in printing and dyeing. Accidental or deliberate ingestion of bromate solution has rarely been reported in Korea. The clinical manifestations of bromate intoxication are vomiting, diarrhea, central nervous system symptoms, oliguric or non-oliguric acute kidney injury, hemolytic anemia, and deafness; most of these manifestations are reversible, with the exception of renal failure and deafness. Here, we report on two patients who demonstrated distinct clinical progressions. In the first case, a 16-year-old woman was successfully treated with hemodialysis and recovered renal function without hearing loss. However, in the second case, delayed hemodialysis resulted in persistent renal failure and hearing loss in a 77-year-old woman. This suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, as the rapid removal of bromate may be essential to preventing severe intoxication and its sequelae.

• Authors: Dong Hwan Ryu, Kyung Ae Jang, Seok Min Kim, Jong Won Park, Jun Young Do, Kyung Woo Yoon
• Journal: The Korean journal of internal medicine (Korean J Intern Med) Vol. 26 Issue 4 Pg. 463-5 (Dec 2011) ISSN: 2005-6648 [Electronic] Korea (South)
• PMID: 22205849 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bromates
• Sodium Compounds
• sodium bromate

Topics

• Acute Kidney Injury (chemically induced, therapy)
• Adolescent
• Aged
• Bromates (toxicity)
• Fatal Outcome
• Female
• Hearing Loss
• Humans
• Kidney Failure, Chronic (therapy)
• Renal Dialysis
• Sodium Compounds (toxicity)