Efficacy of pivmecillinam for treatment of lower urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae.

Abstract

To evaluate the clinical and bacteriological efficacy of pivmecillinam against lower urinary tract infection (UTI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, patients treated for lower UTI with pivmecillinam (n=8) were studied. Patients treated with nitrofurantoin (n=3) and trimethoprim (n=3) or a combination of these agents with pivmecillinam (n=3) were included as a control group. Antimicrobial susceptibility was determined with EUCAST methodology. Bacteriologic cure was defined as <10(3) CFU/ml at follow-up (30 days), and clinical cure as resolved UTI symptoms after completed treatment. All patients receiving pivmecillinam had good clinical response (8/8), but bacteriological cure rates were low (2/8). However, none of the patients with persisting bacteriuria had a relapse of UTI symptoms within 6 months. All isolates were susceptible to the given antimicrobial. Most isolates belonged to the CTX-M-1 group (n=11, 65%) or CTX-M-9-group (n=4, 24%). Four E. coli isolates belonged to the international clone O25b-ST131 (25%). In conclusion, pivmecillinam had good clinical activity against lower UTI caused by ESBL-producing Enterobacteriaceae, but bacteriological cure rates were low. The persistent bacteriuria appears to be of little clinical importance, but larger clinical studies are needed to determine the usefulness of pivmecillinam in infections caused by ESBL-producing bacteria.

• Authors: Emilia Titelman, Aina Iversen, Mats Kalin, Christian G Giske
• Journal: Microbial drug resistance (Larchmont, N.Y.) (Microb Drug Resist) Vol. 18 Issue 2 Pg. 189-92 (Apr 2012) ISSN: 1931-8448 [Electronic] United States
• PMID: 22204597 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Amdinocillin Pivoxil
• beta-Lactamases

Topics

• Amdinocillin Pivoxil (pharmacology, therapeutic use)
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Escherichia coli (drug effects, enzymology, isolation & purification)
• Escherichia coli Infections (drug therapy, microbiology)
• Feces (microbiology)
• Female
• Follow-Up Studies
• Humans
• Klebsiella Infections (drug therapy, microbiology)
• Klebsiella pneumoniae (drug effects, enzymology, isolation & purification)
• Male
• Microbial Sensitivity Tests
• Treatment Outcome
• Urinary Tract Infections (drug therapy, microbiology)
• Urine (microbiology)
• beta-Lactamases (biosynthesis, genetics)