[A case of metastatic rectal cancer in an extremely aged patient successfully treated with mFOLFOX6 plus bevacizumab].

The safety and usefulness of FOLFOX therapy for elderly patients with metastatic colorectal cancer have not been clarified yet. We report an extremely aged patient case of metastatic colorectal cancer that was treated successfully with modified FOLFOX6 (mFOLFOX6) plus bevacizumab therapy. An 85-year-old man was diagnosed as having a low rectal cancer with paraaortic and left inguinal lymph node involvement. He was given mFOLFOX6 therapy after sigmoid colostomy. Bevacizumab was added to mFOLFOX6 after the second course. Although he experienced grade 2 neurtropenia and grade 1 neurotoxicity, the maximal diameter of the metastatic lymph nodes was decreased to a normal diameter after 9 courses. The primary tumor also disappeared and the biopsy revealed no cancer cells. He remains free of recurrence for 12 months after the end of chemotherapy.
AuthorsMasaru Yokoyama, Masami Urakawa, Tetsuo Murakami, Kunihiko Amano, Tomonori Ohsawa, Norimichi Okada, Kensuke Kumamoto, Keiichiro Ishibashi, Hideyuki Ishida
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2241-3 (Nov 2011) ISSN: 0385-0684 [Print] Japan
PMID22202342 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Organoplatinum Compounds
  • Bevacizumab
  • Leucovorin
  • Fluorouracil
  • Aged, 80 and over
  • Angiogenesis Inhibitors (administration & dosage, therapeutic use)
  • Antibodies, Monoclonal, Humanized (administration & dosage, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Aorta (pathology)
  • Bevacizumab
  • Fluorouracil (administration & dosage, therapeutic use)
  • Humans
  • Leucovorin (administration & dosage, therapeutic use)
  • Lymphatic Metastasis
  • Male
  • Organoplatinum Compounds (administration & dosage, therapeutic use)
  • Rectal Neoplasms (blood supply, drug therapy, pathology, surgery)
  • Tomography, X-Ray Computed

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