Abstract |
The authors used 70% deacetylated chitin and cisplatin (CDDP) to devise a novel anticancer drug delivery system (DDS). We examined in vitro release of the CDDP from the system. The novel system was intraperitoneally( ip) given to malignant ascites-bearing mice, and the survival time of each animal was recorded. The related oncolytic mechanism was immunologically investigated. More than 70-90% of the CDDP was gradually delivered from the system in 24 hours. Nineteen animals among 30 treated with our system survived for longer than 4 weeks, and a recurrence of ascites was nil. A 4- week survival rate of the animals with ip injected conventional CDDP was 5/14. All non-treated animals had massive ascites and died within 4 weeks. Immunologic studies suggested that cytotoxic immunoresponse was induced in the mice treated with the novel system. Our newly devised system warrants for clinical applications in the treatment of malignant ascites.
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Authors | Tetsuya Itabashi, Akio Sugitachi, Yusuke Kimura, Miyuki Ikeda, Manami Kumagai, Teppei Matsuo, Hitoshi Fujii, Satoshi Nishizuka, Koki Otsuka, Keisuke Koeda, Akira Sasaki, Go Wakabayashi |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 38
Issue 12
Pg. 2081-3
(Nov 2011)
ISSN: 0385-0684 [Print] Japan |
PMID | 22202290
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Cisplatin
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Ascites
(drug therapy, etiology)
- CD8-Positive T-Lymphocytes
(immunology)
- Cell Line, Tumor
- Cisplatin
(administration & dosage, therapeutic use)
- Drug Delivery Systems
- Injections, Intraperitoneal
- Mice
- Neoplasm Transplantation
- Peritoneal Neoplasms
(complications, drug therapy, immunology)
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