[A novel Cisplatin delivery system for malignant ascites-bearing mice-a basic experimentation].

Abstract

The authors used 70% deacetylated chitin and cisplatin (CDDP) to devise a novel anticancer drug delivery system (DDS). We examined in vitro release of the CDDP from the system. The novel system was intraperitoneally( ip) given to malignant ascites-bearing mice, and the survival time of each animal was recorded. The related oncolytic mechanism was immunologically investigated. More than 70-90% of the CDDP was gradually delivered from the system in 24 hours. Nineteen animals among 30 treated with our system survived for longer than 4 weeks, and a recurrence of ascites was nil. A 4- week survival rate of the animals with ip injected conventional CDDP was 5/14. All non-treated animals had massive ascites and died within 4 weeks. Immunologic studies suggested that cytotoxic immunoresponse was induced in the mice treated with the novel system. Our newly devised system warrants for clinical applications in the treatment of malignant ascites.

• Authors: Tetsuya Itabashi, Akio Sugitachi, Yusuke Kimura, Miyuki Ikeda, Manami Kumagai, Teppei Matsuo, Hitoshi Fujii, Satoshi Nishizuka, Koki Otsuka, Keisuke Koeda, Akira Sasaki, Go Wakabayashi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2081-3 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202290 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Ascites (drug therapy, etiology)
• CD8-Positive T-Lymphocytes (immunology)
• Cell Line, Tumor
• Cisplatin (administration & dosage, therapeutic use)
• Drug Delivery Systems
• Injections, Intraperitoneal
• Mice
• Neoplasm Transplantation
• Peritoneal Neoplasms (complications, drug therapy, immunology)