MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.

Abstract

Melanoma differentiation associated gene-9 (MDA-9), synonymous with syntenin, is an adapter protein that provides a central role in regulating cell-cell and cell-matrix adhesion. MDA-9/syntenin transduces signals from the cell-surface to the interior through its interaction with a plethora of additional proteins and actively participates in intracellular trafficking and cell-surface targeting, synaptic transmission, and axonal outgrowth. Recent studies demarcate a seminal role of MDA-9/syntenin in cancer metastasis. In the context of melanoma, MDA-9/syntenin functions as a positive regulator of melanoma progression and metastasis through interactions with c-Src and promotes the formation of an active FAK/c-Src signaling complex leading to NF-k B and matrix metalloproteinase (MMP) activation. The present review provides a current perspective of our understanding of the important features of MDA-9/syntenin and its significant role in tumor cell metastasis with special focus on molecular mechanism of action.

• Authors: Swadesh K Das, Sujit K Bhutia, Timothy P Kegelman, Leyla Peachy, Regina A Oyesanya, Santanu Dasgupta, Upneet K Sokhi, Belal Azab, Rupesh Dash, Bridget A Quinn, Keetae Kim, Paola M Barral, Zhao-zhong Su, Habib Boukerche, Devanand Sarkar, Paul B Fisher
• Journal: Frontiers in bioscience (Landmark edition) (Front Biosci (Landmark Ed)) Vol. 17 Issue 1 Pg. 1-15 (01 01 2012) ISSN: 2768-6698 [Electronic] Singapore
• PMID: 22201728 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Enzyme Precursors
• Multiprotein Complexes
• SDCBP protein, human
• Syndecans
• Syntenins
• Tumor Suppressor Proteins
• Focal Adhesion Kinase 1
• PTK2 protein, human
• Proto-Oncogene Proteins pp60(c-src)
• Gelatinases
• progelatinase

Topics

• Enzyme Precursors (metabolism)
• Focal Adhesion Kinase 1 (chemistry, metabolism)
• Gelatinases (metabolism)
• Humans
• Melanoma (pathology, physiopathology, secondary)
• Models, Biological
• Multiprotein Complexes (chemistry)
• Nervous System (physiopathology)
• Protein Interaction Domains and Motifs
• Proto-Oncogene Proteins pp60(c-src) (chemistry, metabolism)
• Signal Transduction
• Syndecans (metabolism)
• Syntenins (chemistry, genetics, physiology)
• Tumor Suppressor Proteins (chemistry, genetics, physiology)