[Odontoclasts and calcitonin].

Abstract

Although it is believed that odontoclasts, which mediated root resorption of deciduous teeth, possess common properties to osteoclasts, these regulatory mechanisms differ from osteoclastic bone resorption. It is well established that calcitonin receptor is an important osteoclast marker and that calcitonin is a potent inhibitory hormone of osteoclastic bone resorption. However, the presence and function of calcitonin receptors in human odontoclasts are still controversial. We summarize the physiological properties and differentiation mechanisms of odontoclasts, and the effects of calcitonin on root resorption, including our recent results using human odontoclasts and periodontal ligament cells freshly isolated from deciduous tooth roots.

• Authors: Koji Okabe, Fujio Okamoto, Hiroshi Kajiya
• Journal: Clinical calcium (Clin Calcium) Vol. 22 Issue 1 Pg. 19-26 (Jan 2012) ISSN: 0917-5857 [Print] Japan
• PMID: 22201095 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• RANK Ligand
• Receptors, Calcitonin
• Calcitonin

Topics

• Animals
• Calcitonin (physiology)
• Cell Differentiation
• Humans
• Osteoclasts (metabolism, physiology)
• Periodontal Ligament (cytology)
• RANK Ligand (physiology)
• Receptors, Calcitonin (metabolism, physiology)
• Root Resorption
• Signal Transduction (physiology)
• Tooth, Deciduous (cytology)