Abstract |
Ten critically-ill preterm infants with severe hyaline membrane disease received tolazoline because of persistent hypoxemia refractory to the administration of 100% oxygen and mechanical ventilation. Seven infants (70%) responded immediately with an increase in PaO2 greater than or equal to 20 mmHg in the umbilical arterial gas within 60 minutes after bolus infusion (1 to 2 mg/kg) of tolazoline. Twenty-four hours later after the tolazoline infusion, the FiO2 had been decreased from 1.0 to a mean of 0.82 +/- 0.16, and the MAP from 16.5 +/- 1.8 to 15.6 +/- 4.5 cm H2O. Four of 7 infants (57%) who had an immediate response survived, whereas none survived out of 3 infants who failed to respond initially. Three infants experienced relatively severe complications possibly related to tolazoline. There appears to be a place for the use of tolazoline in a severely hypoxemic infant with hyaline membrane disease who is being ventilated, and in whom arterial oxygenation cannot be improved by a further increase in the inspired oxygen concentration or by an alteration of ventilator settings.
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Authors | K I Park, R Namgung, C Lee, D G Han |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 31
Issue 2
Pg. 156-62
(Jun 1990)
ISSN: 0513-5796 [Print] Korea (South) |
PMID | 2219973
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Humans
- Hyaline Membrane Disease
(complications)
- Hypoxia
(drug therapy)
- Infant
- Infant, Newborn
- Infusions, Intravenous
- Tolazoline
(administration & dosage, therapeutic use)
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