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Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin.

Abstract
The present study further investigated the mode of action of methyl jasmonate (MJ) in different cervical cancer cell lines. We show that in addition to the short term cytotoxicity, MJ effectively reduced the survival of cervical cancer cells (clonogenicity assays). MJ induced apoptosis in all cervical cancer cells. In some cell lines, MJ caused elevation of the mitochondrial superoxide anion, notably, in HeLa and CaSki. Changes in the expression of p53 and bax were variable, yet, downregulation of survivin was common to all cervical cancer cells. MJ significantly reduced the levels of the human papillomavirus (HPV) E6 and E7 proteins without alteration of the mRNA levels. Moreover, ectopic expression of E6, E7 or both in cervical cancer cells that lack HPV (C33A), did not alter significantly their response to MJ. Our studies point to MJ as an effective anticancer agent against a variety of cervical cancer cells acting through shared and different pathways to induce cell death regardless of the presence of HPV.
AuthorsElad Milrot, Anna Jackman, Tatiana Kniazhanski, Pinhas Gonen, Eliezer Flescher, Levana Sherman
JournalCancer letters (Cancer Lett) Vol. 319 Issue 1 Pg. 31-8 (Jun 01 2012) ISSN: 1872-7980 [Electronic] Ireland
PMID22198483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Acetates
  • Antineoplastic Agents
  • BIRC5 protein, human
  • Cyclopentanes
  • DNA-Binding Proteins
  • E6 protein, Human papillomavirus type 16
  • E6 protein, Human papillomavirus type 18
  • Inhibitor of Apoptosis Proteins
  • Oncogene Proteins, Viral
  • Oxylipins
  • Papillomavirus E7 Proteins
  • Repressor Proteins
  • Survivin
  • methyl jasmonate
Topics
  • Acetates (pharmacology)
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cyclopentanes (pharmacology)
  • DNA-Binding Proteins (drug effects, metabolism)
  • Down-Regulation
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Inhibitor of Apoptosis Proteins (drug effects, metabolism)
  • Oncogene Proteins, Viral (drug effects, metabolism)
  • Oxylipins (pharmacology)
  • Papillomavirus E7 Proteins (metabolism)
  • Repressor Proteins (drug effects, metabolism)
  • Survivin
  • Uterine Cervical Neoplasms (drug therapy, metabolism)

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