Abstract | OBJECTIVE: RESEARCH DESIGN AND METHOD: Diabetic rats were treated with Re (40mg/kg) for 8weeks, blood glucose and body weight were measured monthly and weekly, respectively. Cognitive performances were evaluated with Morris water maze. Brain was obtained for measurements of TNF-α and malondialdehyde (MDA) contents in both temporal cortex and hippocampus, blood was collected for assays of TNF-α, MDA and reduced glutathione (GSH) levels. RESULTS: Learning and memory abilities were significantly (both P<0.01) impaired in diabetic rats, accompanied by the marked (all P<0.01) elevations of TNF-α and MDA levels in temporal cortex and hippocampus. Increment of MDA and decrement of GSH in serum also occurred with significant differences (both P<0.01). Chronic treatment with Re markedly (P<0.05) improved the cognition of diabetic rats, evidenced by the decreased escape latency and the increased percentage of time spent in the target quadrant. Furthermore, Re treatment remarkably (P<0.05) reduced the levels of TNF-α and MDA in both brain areas of diabetic rats. Decline of MDA level and elevation of GSH level in serum were also seen in Re-treated diabetic rats, coupled with decrease in serum glucose level, all with statistically significant differences. CONCLUSIONS:
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Authors | Yao-Wu Liu, Xia Zhu, Wei Li, Qian Lu, Jian-Yun Wang, Ya-Qin Wei, Xiao-Xing Yin |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 101
Issue 1
Pg. 93-8
(Mar 2012)
ISSN: 1873-5177 [Electronic] United States |
PMID | 22197711
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Blood Glucose
- Ginsenosides
- Tumor Necrosis Factor-alpha
- ginsenoside Re
- Malondialdehyde
- Glutathione
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Blood Glucose
(metabolism)
- Body Weight
(drug effects)
- Brain Chemistry
(drug effects)
- Cognition Disorders
(drug therapy, etiology, psychology)
- Diabetes Mellitus, Experimental
(complications, psychology)
- Ginsenosides
(pharmacology)
- Glutathione
(blood)
- Inflammation
(etiology, pathology)
- Lipid Peroxidation
(drug effects)
- Male
- Malondialdehyde
(metabolism)
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha
(blood, metabolism)
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