Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy.

Abstract

The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent intensities of the FL-SBL-labeled DSPC liposomes increased with the increase of the additive FL-SBL, and the maximum emission wavelength of the liposomes appeared at 531 nm. A preliminary in vivo imaging study of tumor-bearing mice revealed that the FL-SBL-labeled DSPC liposomes were delivered to the tumor tissue but not distributed to hypoxic regions.

• Authors: Hiroyuki Nakamura, Noriko Ueda, Hyun Seung Ban, Manabu Ueno, Shoji Tachikawa
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 10 Issue 7 Pg. 1374-80 (Feb 21 2012) ISSN: 1477-0539 [Electronic] England
• PMID: 22193924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Boron Compounds
• Liposomes
• Oxadiazoles
• Phosphatidylcholines
• Phosphatidylethanolamines
• Stearates
• polyethylene glycol-distearoylphosphatidylethanolamine
• dodecaborate
• Polyethylene Glycols
• 1,2-distearoyllecithin
• Boron

Topics

• Animals
• Boron (administration & dosage, chemistry)
• Boron Compounds (chemical synthesis, chemistry)
• Drug Delivery Systems
• Female
• Fluorescence
• Liposomes (administration & dosage, chemical synthesis)
• Mice
• Neoplasms (radiotherapy)
• Oxadiazoles (chemical synthesis, chemistry)
• Phosphatidylcholines (chemistry)
• Phosphatidylethanolamines (chemistry)
• Polyethylene Glycols (chemistry)
• Stearates (chemical synthesis, chemistry)
• Tissue Distribution