Chemical compositions and anti-influenza activities of essential oils from Mosla dianthera.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Mosla dianthera as an aromatic herb is used in folk medicine for the treatment of cough, colds, fever, bronchitis, nasal congestion and headache.

AIM OF THE STUDY:

To characterize chemical compositions and to evaluate the anti-influenza effects of essential oils of M. dianthera (MDEO) in influenza virus A (IVA) infected mice.

MATERIALS AND METHODS:

MDEO was obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry (GC-MS). ICR mice were treated with MDEO for 5 consecutive days at doses of 90-360 mg/kg after post-infected. Levels of Serum IL-4 and IFN-γ were assayed by ELISA. Levels of MOD, SOD, TAOC and GSH-Px in lung tissue were determined by colorimetric method.

RESULTS:

GC-MS analysis revealed the presence of 29 components that account for 97.74% of phenolic sesquiterpenes and aromatic compounds. The major compounds were elemicin (16.51%), thymol (14.77%), β-caryophyllene (14.49%), iso-elemicin (9.22%), asarone (6.09%) and α-caryophyllene (5.26%). It had significant effects on decreasing lung viral titers, inhibiting pneumonia, reducing levels of serum IFN-γ and IL-4, and enhancing antioxidant activity in the lung tissue of IVA infected mice.

CONCLUSIONS:

MPE could exhibit therapeutical effects in IVA infected mice as a suppressor of IVA replication and inflammatory mediators and a promoter of antioxidant potentials. Therefore, MDEO could provide a safe and effective therapeutic candidate for treatment of influenza and its subsequent viral pneumonia.

• Authors: Qiao-feng Wu, Wei Wang, Xiao-yan Dai, Zhi-yuan Wang, Zhen-hua Shen, Hua-zhong Ying, Chen-huan Yu
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 139 Issue 2 Pg. 668-71 (Jan 31 2012) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 22193174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• Inflammation Mediators
• Oils, Volatile
• Plant Oils
• Interleukin-4
• Ribavirin
• Malondialdehyde
• Interferon-gamma
• Glutathione Peroxidase
• Superoxide Dismutase

Topics

• Animals
• Antiviral Agents (chemistry, isolation & purification, pharmacology, toxicity)
• Colorimetry
• Disease Models, Animal
• Enzyme-Linked Immunosorbent Assay
• Gas Chromatography-Mass Spectrometry
• Glutathione Peroxidase (metabolism)
• Inflammation Mediators (blood)
• Influenza A Virus, H1N1 Subtype (drug effects, pathogenicity)
• Interferon-gamma (blood)
• Interleukin-4 (blood)
• Lamiaceae (chemistry)
• Lung (drug effects, metabolism, pathology, virology)
• Malondialdehyde (metabolism)
• Mice
• Mice, Inbred ICR
• Oils, Volatile (chemistry, isolation & purification, pharmacology, toxicity)
• Orthomyxoviridae Infections (blood, drug therapy, pathology, virology)
• Plant Components, Aerial
• Plant Oils (chemistry, isolation & purification, pharmacology, toxicity)
• Plants, Medicinal
• Ribavirin (pharmacology)
• Superoxide Dismutase (metabolism)
• Virus Replication (drug effects)