Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl.

Abstract

This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.

• Authors: Marija Jelušić, Katarina Starčević, Mandica Vidović, Savko Dobrota, Kristina Potočki, Ljiljana Banfić, Branimir Anić
• Journal: Rheumatology international (Rheumatol Int) Vol. 33 Issue 5 Pg. 1359-62 (May 2013) ISSN: 1437-160X [Electronic] Germany
• PMID: 22190275 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antiphospholipid
• Anticoagulants
• Biomarkers
• Fibrinolytic Agents
• Warfarin
• Tissue Plasminogen Activator

Topics

• Administration, Oral
• Adolescent
• Angiography, Digital Subtraction
• Antibodies, Antiphospholipid (blood)
• Anticoagulants (administration & dosage)
• Antiphospholipid Syndrome (blood, complications, diagnosis, genetics, immunology)
• Arterial Occlusive Diseases (blood, diagnosis, drug therapy, etiology)
• Biomarkers (blood)
• Constriction, Pathologic
• Female
• Fibrinolytic Agents (therapeutic use)
• Genetic Predisposition to Disease
• Heredity
• Humans
• Ischemia (etiology)
• Pedigree
• Popliteal Artery (diagnostic imaging)
• Radial Artery (diagnostic imaging)
• Thrombolytic Therapy
• Tissue Plasminogen Activator (therapeutic use)
• Treatment Outcome
• Warfarin (administration & dosage)