Abstract |
We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).
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Authors | Gary L Darmstadt, Saskia J M Osendarp, Saifuddin Ahmed, Candace Feldman, Joop M A Van Raaij, Abdullah H Baqui, J G A J Hautvast, George J Fuchs |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 31
Issue 4
Pg. 407-9
(Apr 2012)
ISSN: 1532-0987 [Electronic] United States |
PMID | 22189527
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Bangladesh
(epidemiology)
- Diet
(methods)
- Dietary Supplements
- Double-Blind Method
- Female
- Humans
- Impetigo
(epidemiology, prevention & control)
- Incidence
- Infant
- Infant, Newborn
- Male
- Placebos
(administration & dosage)
- Pregnancy
- Zinc
(administration & dosage)
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