Abstract | AIMS: METHODS: RESULTS: ADMA levels and CIMT measurements were significantly higher in NAFLD group than the controls. However, the difference regarding the CIMT disappeared when the findings were adjusted according to the metabolic parameters and insulin sensitivity. In contrast, the difference for ADMA remained significant between two groups. No significant association was found between ADMA, CIMT and histopathological findings. CONCLUSIONS: Plasma ADMA levels are increased in subjects with NAFLD. This increase seems to be independent from traditional cardiovascular risk factors, insulin resistance and liver histology. Circulating ADMA may be an earlier marker of vascular damage with respect to CIMT in subjects with NAFLD.
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Authors | Teoman Dogru, Halil Genc, Serkan Tapan, Cemal Nuri Ercin, Fatih Ors, Fatih Aslan, Muammer Kara, Erdim Sertoglu, Sait Bagci, Ismail Kurt, Alper Sonmez |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 96
Issue 1
Pg. 47-52
(Apr 2012)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 22189171
(Publication Type: Journal Article)
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Copyright | Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- N,N-dimethylarginine
- Arginine
|
Topics |
- Adult
- Arginine
(analogs & derivatives, blood)
- Biomarkers
(blood)
- Carotid Artery Diseases
(blood, diagnostic imaging)
- Carotid Intima-Media Thickness
- Fatty Liver
(blood)
- Humans
- Male
- Non-alcoholic Fatty Liver Disease
- Young Adult
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