[Comparative analysis between breath test, serological immunoassay and rapid-urease test for detection of Helicobacter pylori infection in Mexican patients with non-investigated dyspepsia].

Abstract

INTRODUCTION:

There are multiple Helicobacter pylori (Hp) detection tests, some are invasive and other noninvasive. The diagnostic accuracy of these methods varies according to the prevalence of the disease.

OBJECTIVE:

To determine the diagnostic accuracy of the breath test, serology and rapid urease test, considering gastric biopsy with Giemsa stain as the gold standard in Hp-infected subjects with uninvestigated dyspepsia.

METHODS:

Eighty four subjects (64 women, mean age 45 years) who were referred for dyspeptic symptoms were evaluated. Also, 20 healthy volunteers (12 men, average age 38 years) were evaluated. All the subjects underwent hystological analysis with Giemsa stain, breath test (Heliprobe®), rapid urease test (CLOtest®) and serological immunoassay (Hexagon®).

RESULTS:

Overall, Hp infection was diagnosed by histological analysis in 59 subjects (49 patients and 10 healthy subjects). Positivity to breath test, rapid urease test and serology were 56%, 46% and 44% respectively. Agreement with the histological analysis was 0.902 for the breath test, 0.620 for rapid urease test and 0.45 for serology. The area under the curve for the breath test was 0.95, for the rapid urease test was 0.82 and for serological test was 0.74.

CONCLUSIONS:

In our population, the breath test shown to have a diagnostic accuracy equivalent to histological analysis by Giemsa in subjects with uninvestigated dyspepsia.

• Authors: G Alarcón-Rivera, G Vázquez-Jiménez, E de la Cruz-Patiño, M Abarca, E Leyva, F Delgado, I Ruíz-Juárez, P Grube-Pagola, F Roesch-Dietlen, J M Remes-Troche
• Journal: Revista de gastroenterologia de Mexico (Rev Gastroenterol Mex) 2011 Oct-Dec Vol. 76 Issue 4 Pg. 322-9 ISSN: 0375-0906 [Print] Mexico
• Vernacular Title: Un análisis comparativo entre prueba de aliento, serología y prueba de ureasa rápida para la detección de infección por Helicobacter pylori en pacientes mexicanos con dispepsia no investigada.
• PMID: 22188957 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Urease

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Breath Tests
• Cross-Sectional Studies
• Dyspepsia (etiology)
• Female
• Helicobacter Infections (complications, diagnosis)
• Helicobacter pylori
• Humans
• Immunoassay
• Male
• Middle Aged
• Serologic Tests
• Urease
• Young Adult