Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study.

Abstract	Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [(11)C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A V(T), an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa-levodopa administration (P<0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.
Authors	Julia Sacher, Eugenii A Rabiner, Michael Clark, Pablo Rusjan, Alexandra Soliman, Rada Boskovic, Stephen J Kish, Alan A Wilson, Sylvain Houle, Jeffrey H Meyer
Journal	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 32 Issue 3 Pg. 443-6 (Mar 2012) ISSN: 1559-7016 [Electronic] United States
PMID	22186668 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Carbon Radioisotopes Dopamine Agonists Drug Combinations carbidopa, levodopa drug combination Serotonin Levodopa Harmine Tryptophan Monoamine Oxidase Carbidopa Dopamine
Topics	Carbidopa (administration & dosage, blood, pharmacology) Carbon Radioisotopes Corpus Striatum (enzymology, metabolism) Dopamine (metabolism) Dopamine Agonists (administration & dosage, blood, pharmacology) Drug Combinations Harmine (metabolism) Humans Levodopa (administration & dosage, blood, pharmacology) Monoamine Oxidase (metabolism) Parkinson Disease (enzymology) Positron-Emission Tomography Prefrontal Cortex (enzymology, metabolism) Protein Binding Serotonin (metabolism) Substrate Specificity Time Factors Tryptophan (blood)

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