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A fatal case of severe methaemoglobinemia due to nitrobenzene poisoning.

Abstract
An acute poisoning with nitrobenzene presenting as methaemoglobinemia is an uncommon medical emergency. A young girl with nitrobenzene induced methaemoglobinaemia died despite use of mechanical ventilator, administration of oral methylene blue and parenteral ascorbic acid. Here author highlights the rare occurrence of such cases, methaemoglobin induced severe oxidative stress, unexplained splenomegaly and leucocytosis and the ineffectivity of oral methylene blue and other supportive measures in evading death due to nitrobenzene poisoning.
AuthorsAlok Gupta, Nirdesh Jain, Avinash Agrawal, Arjun Khanna, Manish Gutch
JournalEmergency medicine journal : EMJ (Emerg Med J) Vol. 29 Issue 1 Pg. 70-1 (Jan 2012) ISSN: 1472-0213 [Electronic] England
PMID22186264 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antidotes
  • Nitrobenzenes
  • Ascorbic Acid
  • Methylene Blue
Topics
  • Adolescent
  • Antidotes (administration & dosage)
  • Ascorbic Acid (administration & dosage)
  • Fatal Outcome
  • Female
  • Humans
  • Methemoglobinemia (chemically induced)
  • Methylene Blue (administration & dosage)
  • Nitrobenzenes (poisoning)
  • Suicide

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