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Effect of bilastine upon nasal obstruction.

Abstract
H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these drugs have been considered effective in controlling sneezing, rhinorrhea and itching, though they have not been regarded as particularly effective in application to nasal obstruction. The most recent studies, involving second-generation H1 antihistamines (desloratadine, fexofenadine, levocetirizine, rupatadine), have shown these drugs to offer effects upon nasal obstruction significantly superior to those of placebo. The present review examines the effect of bilastine, a new, potent and highly specific H1 antihistamine without sedative effects or cardiac toxicity, upon nasal obstruction. The analysis of the data from the different clinical trials indicates that in patients with allergic rhinitis, the effect of bilastine upon nasal obstruction is superior to that of placebo and similar to that of other second-generation H1 antihistamines, manifesting within 24 hours after the start of treatment.
AuthorsI Dávila, J Sastre, J Mullol, J Montoro, I Jáuregui, M Ferrer, A del Cuvillo, J Bartra, A Valero
JournalJournal of investigational allergology & clinical immunology (J Investig Allergol Clin Immunol) Vol. 21 Suppl 3 Pg. 2-8 ( 2011) ISSN: 1018-9068 [Print] Spain
PMID22185044 (Publication Type: Journal Article, Review)
Chemical References
  • Benzimidazoles
  • Histamine H1 Antagonists
  • Piperidines
  • bilastine
Topics
  • Benzimidazoles (pharmacology, therapeutic use)
  • Clinical Trials as Topic
  • Histamine H1 Antagonists (therapeutic use)
  • Humans
  • Nasal Obstruction (drug therapy)
  • Piperidines (pharmacology, therapeutic use)
  • Rhinitis, Allergic, Perennial (drug therapy)
  • Rhinitis, Allergic, Seasonal (drug therapy)

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