Abstract | CONTEXT: OBJECTIVE: DESIGN, SETTING AND PARTICIPANTS: UK hospital-based cohort study of 396 men with prostate cancer, diagnosed between 1990 and 2008, with mean follow-up of 3.7 years. MAIN OUTCOME MEASURES: RESULTS: In men with advanced cancer, there was some evidence that IGF-I was positively associated (HR 1.20; 95% CI: 0.96, 1.49; p = 0.11) and IGFBP-3 was inversely associated (HR 0.84; 95% CI: 0.70, 1.01; p = 0.07) with all-cause mortality after controlling for age, treatment status, smoking, prostate-specific antigen and Gleason grade at diagnosis. There was some evidence that IGF-I was positively associated with prostate cancer mortality in advanced cases (HR 1.23; 95% CI: 0.94, 1.62; p = 0.13). In advanced cancers, associations of IGF-I with all-cause (HR 1.68; 95% CI: 1.28, 2.23; p < 0.001) and prostate cancer-specific (HR 1.59; 95% CI: 1.11, 2.28; p = 0.01) mortality strengthened (and were conventionally statistically significant) after further controlling for IGFBP-3. CONCLUSIONS: Measures of IGF-I and IGFBP-3 may have potential as prognostic markers in predicting risk of death in men with advanced prostate cancer. Large, prospective studies with repeat IGFs and IGFBPs are now required.
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Authors | Mari-Anne Rowlands, Jeff M P Holly, Freddie Hamdy, Joshua Phillips, Louise Goodwin, Gemma Marsden, David Gunnell, Jenny Donovan, David E Neal, Richard M Martin |
Journal | Cancer causes & control : CCC
(Cancer Causes Control)
Vol. 23
Issue 2
Pg. 347-54
(Feb 2012)
ISSN: 1573-7225 [Electronic] Netherlands |
PMID | 22183619
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IGF2 protein, human
- IGFBP3 protein, human
- Insulin-Like Growth Factor Binding Protein 2
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
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Topics |
- Aged
- Aged, 80 and over
- Cohort Studies
- Disease Progression
- Follow-Up Studies
- Humans
- Insulin-Like Growth Factor Binding Protein 2
(metabolism)
- Insulin-Like Growth Factor Binding Protein 3
(metabolism)
- Insulin-Like Growth Factor I
(metabolism)
- Insulin-Like Growth Factor II
(metabolism)
- Male
- Neoplasm Staging
- Prognosis
- Prospective Studies
- Prostatic Neoplasms
(blood, metabolism, mortality)
- Risk Factors
- United Kingdom
(epidemiology)
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