Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats.

Abstract

A comparative study was designed and conducted to compare the pharmacokinetic difference of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra to normal rats and the acute cholestasis hepatitis rats induced by alpha-naphthylisothiocyanate (ANIT). UPLC-ESI-MS/MS method was employed to determine the level of paeoniflorin and albiflorin in rat plasma using geniposide as the internal standard (IS). Unpaired Student's t-test was used for the statistical comparison. The investigation showed that there were significant differences between the normal rats and the acute cholestasis hepatitis rat groups in calculated parameters, such as AUC(0-t), AUC(0-∞), T(max) and CLz/F. The results indicated that acute liver injury in rats could alter the pharmacokinetics of drug. Since patients are the final users of the drug, it is essential to investigate the pharmacokinetics of the drug in disease status. Therefore, we used normal rats and the acute cholestasis hepatitis rats to study pharmacokinetics of Radix Paeoniae Rubra with the purpose of examining the influence of disease on the metabolic course.

• Authors: Fengjuan Jiang, Yanling Zhao, Jiabo Wang, Sisi Wei, Zhenman Wei, Ruisheng Li, Yun Zhu, Zhiyong Sun, Xiaohe Xiao
• Journal: Fitoterapia (Fitoterapia) Vol. 83 Issue 2 Pg. 415-21 (Mar 2012) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 22183079 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Benzoates
• Bridged-Ring Compounds
• Drugs, Chinese Herbal
• Glucosides
• Monoterpenes
• peoniflorin
• albiflorin

Topics

• Acute Disease
• Administration, Oral
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, chemistry, pharmacokinetics)
• Benzoates (administration & dosage, chemistry, pharmacokinetics)
• Bridged-Ring Compounds (administration & dosage, chemistry, pharmacokinetics)
• Cholestasis (drug therapy)
• Drugs, Chinese Herbal (administration & dosage, chemistry, pharmacokinetics)
• Glucosides (administration & dosage, chemistry, pharmacokinetics)
• Hepatitis (drug therapy)
• Humans
• Male
• Monoterpenes
• Paeonia (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Sensitivity and Specificity
• Time Factors