Squaraine dyes in PDT: from basic design to in vivo demonstration.

Abstract

The design and development of novel squaraine dyes as sensitisers for photodynamic therapy (PDT) applications has grown tremendously in the last decade from the time when a squaraine dye was proposed to be a potential candidate, to-date when the use of such dyes have been demonstrated in animal models for skin cancer. This perspective article highlights the basic design, tuning of absorption, triplet excited state and two-photon absorption properties and recent developments of the squaraines as PDT sensitisers.

• Authors: Rekha R Avirah, Dhanya T Jayaram, Nagappanpillai Adarsh, Danaboyina Ramaiah
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 10 Issue 5 Pg. 911-20 (Feb 07 2012) ISSN: 1477-0539 [Electronic] England
• PMID: 22179414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclobutanes
• Drug Carriers
• Phenols
• Photosensitizing Agents
• squaraine

Topics

• Animals
• Cell Line, Tumor
• Cyclobutanes (administration & dosage, chemistry, therapeutic use)
• Drug Carriers (chemistry)
• Drug Design
• Humans
• Mice
• Models, Molecular
• Neoplasms (drug therapy)
• Phenols (administration & dosage, chemistry, therapeutic use)
• Photochemotherapy
• Photosensitizing Agents (administration & dosage, chemistry, therapeutic use)