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Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.

Abstract
The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.
AuthorsMagali Gary-Bobo, Ouahiba Hocine, David Brevet, Marie Maynadier, Laurence Raehm, Sébastien Richeter, Virginie Charasson, Bernard Loock, Alain Morère, Philippe Maillard, Marcel Garcia, Jean-Olivier Durand
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 423 Issue 2 Pg. 509-15 (Feb 28 2012) ISSN: 1873-3476 [Electronic] Netherlands
PMID22178618 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Chemical References
  • Drug Carriers
  • Photosensitizing Agents
  • Receptors, Cell Surface
  • galactose receptor
  • Silicon Dioxide
  • Fluorescein
  • Galactose
Topics
  • Cell Death (drug effects)
  • Chemistry, Pharmaceutical
  • Drug Carriers
  • Drug Compounding
  • Endosomes (metabolism)
  • Fluorescein (chemistry, metabolism)
  • Galactose (chemistry, metabolism)
  • HCT116 Cells
  • Humans
  • Lysosomes (metabolism)
  • Microscopy, Confocal
  • Nanoparticles
  • Nanotechnology
  • Neoplasms (metabolism, pathology)
  • Photochemotherapy
  • Photosensitizing Agents (chemistry, metabolism, pharmacology)
  • Porosity
  • Receptors, Cell Surface (metabolism)
  • Silicon Dioxide (chemistry)
  • Technology, Pharmaceutical (methods)
  • Time Factors

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