Fosfomycin: efficacy against infections caused by multidrug-resistant bacteria.

Abstract

OBJECTIVE:

To analyze the indications for and the efficacy of parenteral fosfomycin, especially against multidrug-resistant (MDR) and pan-resistant bacterial infections.

PATIENTS AND METHODS:

During a unique crisis in fosfomycin production, the supply of this antibiotic had to be carefully monitored in France over a 10-week period. One hundred and sixteen assessable patients were included in a prospective cohort study.

RESULTS:

The main indications for use were osteoarthritis, lung infection, urinary tract infection, and bacteraemia. The 2 bacteria most frequently involved were Pseudomonas aeruginosa and methicillin-resistant Staphylococcus. MDR bacteria were seen in 71.5% (83/116) of cases, especially MDR P. aeruginosa (n = 28). Critical situations were common, with 44.0% (51/116) of hospitalizations occurring in an intensive care unit and 22.4% (26/116) of patients with septic shock. The overall outcome was favourable in 76.8% of cases (76/99 assessable patients).

CONCLUSION:

This study provided a unique opportunity to describe the use of fosfomycin and assess its efficacy, especially against MDR bacterial infections, even in critical situations.

• Authors: Aurélien Dinh, Jérôme Salomon, Jean Pierre Bru, Louis Bernard
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 44 Issue 3 Pg. 182-9 (Mar 2012) ISSN: 1651-1980 [Electronic] England
• PMID: 22176655 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Fosfomycin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage, pharmacology)
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, microbiology)
• Child
• Child, Preschool
• Cohort Studies
• Drug Resistance, Multiple, Bacterial
• Female
• Fosfomycin (administration & dosage, pharmacology)
• France
• Humans
• Infant
• Male
• Middle Aged
• Treatment Outcome
• Young Adult