Abstract | AIMS: METHODS: The subjects consisted of 92 patients with bipolar I disorder diagnosed according to DSM-IV, and 170 controls. Plasma total homocysteine, folate and vitamin B12 were measured. MTHFR C677T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Compared with controls, patients had a significantly higher homocysteine level (16.4 ± 9.8 vs 9.6 ± 4.5 µmol/L; P < 0.001) and a significantly lower folate level (3.2 ± 0.9 vs 6.5 ± 3.2 µg/L; P < 0.001). C677T MTHFR polymorphism genotype frequencies were in Hardy-Weinberg equilibrium. After adjustment for MTHFR C677T genotypes, hypofolatemia, hypovitamin B12 and for potential confounding factors, the odds ratio (OR) of hyperhomocysteinemia associated with bipolar disorder remained significant (OR, 5.53; 95% confidence interval: 1.92-15.86; P = 0.001). In patients, there was no significant change in hyperhomocysteinemia, hypofolatemia and hypovitamin B12 with regard to the clinical and therapeutic characteristics, whereas the highest prevalence of hyperhomocysteinemia was found in depressive patients and when illness duration was >12 years. Hypofolatemia was seen in all patients on lithium and in the majority of patients on carbamazepine, and the highest prevalence of hypovitamin B12 was noted in patients taking carbamazepine. CONCLUSION:
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Authors | Asma Ezzaher, Dhouha Haj Mouhamed, Anwar Mechri, Asma Omezzine, Fadoua Neffati, Wahiba Douki, Ali Bouslama, Lotfi Gaha, Mohamed Fadhel Najjar |
Journal | Psychiatry and clinical neurosciences
(Psychiatry Clin Neurosci)
Vol. 65
Issue 7
Pg. 664-71
(Dec 2011)
ISSN: 1440-1819 [Electronic] Australia |
PMID | 22176285
(Publication Type: Journal Article)
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Copyright | © 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology. |
Chemical References |
- Folic Acid
- Methylenetetrahydrofolate Dehydrogenase (NAD+)
- Vitamin B 12
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Topics |
- Adult
- Bipolar Disorder
(blood, metabolism)
- Case-Control Studies
- Female
- Folic Acid
(blood, metabolism)
- Humans
- Hyperhomocysteinemia
(blood, genetics, metabolism)
- Male
- Methylenetetrahydrofolate Dehydrogenase (NAD+)
(genetics)
- Middle Aged
- Odds Ratio
- Polymorphism, Genetic
- Tunisia
- Vitamin B 12
(blood, metabolism)
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